Fractional flow reserve-guided management impacts revascularization decisions and clinical outcomes compared with standard angiography-guided management.
Does fractional flow reserve (FFR)-guided management improve clinical outcomes compared to standard angiography-guided management in patients with stable coronary artery disease and recent myocardial infarction?
This review highlights recent developments demonstrating that FFR-guided management significantly impacts revascularization decisions and clinical outcomes in patients with stable CAD and recent MI.
Coronary artery disease (CAD) is a leading global cause of morbidity and mortality, and improvements in the diagnosis and treatment of CAD can reduce the health and economic burden of this condition. Fractional flow reserve (FFR) is an evidence-based diagnostic test of the physiological significance of a coronary artery stenosis. Fractional flow reserve is a pressure-derived index of the maximal achievable myocardial blood flow in the presence of an epicardial coronary stenosis as a ratio to maximum achievable flow if that artery were normal. When compared with standard angiography-guided management, FFR disclosure is impactful on the decision for revascularization and clinical outcomes. In this article, we review recent developments with FFR in patients with stable CAD and recent myocardial infarction. Specifically, we review novel developments in our understanding of CAD pathophysiology, diagnostic applications, prognostic studies, clinical trials, and clinical guidelines.
Berry et al. (Tue,) conducted a review in Stable coronary artery disease and acute myocardial infarction. Fractional flow reserve (FFR)-guided management vs. Standard angiography-guided management was evaluated. Fractional flow reserve-guided management impacts revascularization decisions and clinical outcomes compared with standard angiography-guided management.