The calcium-regulatory property of troponin T is primarily localized in the troponin T2 region of the C-terminal 101 residues.
Hypothesis-generating in animal models; leaves open therapeutic targeting of troponin T2 pending human validation.
One of the chymotryptic troponin T subfragments, troponin T2, reconstituted approximately 80% of the Ca2+-sensitizing action of troponin T on actomyosin in the presence of troponin C, troponin I, and tropomyosin. This indicates that the Ca2+-regulatory property of troponin T is mostly localized in the troponin T2 region of the C-terminal 101 residues.
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Onoyama et al. (1986) studied this question.
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