Key result
Candesartan acts as an insurmountable and long-lasting antagonist of vascular contractile responses to Ang II, differing from other ARBs by causing a persistent decrease in maximal contractile response.
Candesartan acts as an insurmountable and long-lasting antagonist of vascular contractile responses to Ang II compared to other ARBs.
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May differentiate candesartan from other ARBs in vitro; leaves open clinical translation to hypertension outcomes.
Morsing et al. (1999) studied this question. Candesartan vs. Irbesartan, losartan, and EXP 3174 was evaluated on Maximal contractile response to angiotensin II. Candesartan acts as an insurmountable and long-lasting antagonist of vascular contractile responses to Ang II, differing from other ARBs by causing a persistent decrease in maximal contractile response.
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