Theory of Lipid Metabolism Disorder in Rhinitis and Asthma (Hepato-Lung Axis)

We propose a theory regarding the role of lipid metabolism disorders in rhinitis and asthma. The liver is the most critical organ for lipid metabolism in the body, with bile acids playing the most significant role. Due to space limitations, this article focuses solely on an in-depth discussion and elaboration of the following aspects: the lipid-digesting function of bile acids and their comprehensive physiological effects, as well as their relationships with probiotics, bilirubin, intestinal barrier function, and airway hyperresponsiveness. Existing studies have reported that oral administration of porcine bile powder extract (i.e., the conjugated total bile acids present in porcine bile powder) exhibits expectorant and antitussive effects; in experimental murine bronchial asthma models, this extract reduces inflammatory cell infiltration and alleviates inflammatory cytokine levels. We proposed this hypothesis with the aim of laying the foundation for primary prevention. Concurrently, we are developing a novel drug action pathway centered on bile acids.