What does this research mean for the field?

A hemodynamic profile defined by lactate ≥ 2 mmol/L and Pv-aCO2/ΔAVO2 > 1 is associated with increased morbidity, including higher risks of cerebrovascular events, pneumonia, and acute kidney injury, as well as a critical oxygen delivery (DO2crit) ≤ 7.3 ml/min/kg in patients undergoing cardiac surgery with cardiopulmonary bypass. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to analyze the association between critical oxygen delivery and hemodynamic profiles during cardiac surgery.

June 7, 2026Cirugía CardiovascularOpen Access

Pv-aCO2/ΔAVO2 ratio and lactate define high-risk hemodynamic profiles in cardiac surgery

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Authors

JSJesús Salvador Serrano-García RGRodrigo Gopar-Nieto GRGustavo Rojas-Velasco

Discussion

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Overview

Retrospective study evaluates hemodynamic profiles and outcomes in cardiac surgery, indicating effective risk assessment.

Key Points

The study aims to analyze the association between critical oxygen delivery and hemodynamic profiles during cardiac surgery.
Retrospective analysis of 508 adults undergoing cardiac surgery with CPB.
Patients stratified into three profiles based on lactate levels and Pv-aCO2/ΔAVO2 ratios.
Outcomes assessed using logistic regression adjusted for age and sex.
Profile 2 patients showed higher central venous pressure, elevated Pv-aCO2, and longer CPB times.
Increased risks were observed for cerebrovascular events (OR 4.3), pneumonia (OR 2.0), and acute kidney injury (OR 1.8) in Profile 2.
DO2 crit ≤ 7.3 ml/min/kg was linked to Profile 2 and adverse outcomes.

Cite This Study

Serrano-García et al. (2026) studied this question.

synapsesocial.com/papers/6a250a0b7def13d035e1a50f https://doi.org/10.1016/j.circv.2026.05.002

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June 7, 2026Cirugía CardiovascularOpen Access

Pv-aCO2/ΔAVO2 ratio and lactate define high-risk hemodynamic profiles in cardiac surgery

View Full Paper

Ask AI

Bookmark

Authors

JSJesús Salvador Serrano-García RGRodrigo Gopar-Nieto GRGustavo Rojas-Velasco

Discussion

Member takes

Overview

Retrospective study evaluates hemodynamic profiles and outcomes in cardiac surgery, indicating effective risk assessment.

Key Points

The study aims to analyze the association between critical oxygen delivery and hemodynamic profiles during cardiac surgery.
Retrospective analysis of 508 adults undergoing cardiac surgery with CPB.
Patients stratified into three profiles based on lactate levels and Pv-aCO2/ΔAVO2 ratios.
Outcomes assessed using logistic regression adjusted for age and sex.
Profile 2 patients showed higher central venous pressure, elevated Pv-aCO2, and longer CPB times.
Increased risks were observed for cerebrovascular events (OR 4.3), pneumonia (OR 2.0), and acute kidney injury (OR 1.8) in Profile 2.
DO2 crit ≤ 7.3 ml/min/kg was linked to Profile 2 and adverse outcomes.

Cite This Study

Serrano-García et al. (2026) studied this question.

synapsesocial.com/papers/6a250a0b7def13d035e1a50f https://doi.org/10.1016/j.circv.2026.05.002

View Full Paper

Ask AI

Bookmark