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June 7, 2026Langmuir

Stable Dual-Functional Coating on Polyurethane Surface by Grafting Antibacterial-Zwitterionic Copolymer

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Authors

MZMeiling ZhangHYHuihui YuanJHJiaming Huang

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Overview

Randomized trial demonstrates improved antibacterial and antifouling performance in medical catheters, suggesting enhanced device efficacy.

Key Points

  • The aim is to develop a dual-functional coating to reduce bacterial adhesion and thrombus formation on medical catheters.
  • Grafted an antibacterial-zwitterionic copolymer onto polyurethane surfaces via one-pot polymerization.
  • Utilized polydopamine/polyethylenimine pretreatment for surface immobilization.
  • Evaluated hydrophilicity, protein adsorption resistance, and bactericidal activity of the coating.
  • The water contact angle decreased from 85.95° to 18.25%, indicating improved hydrophilicity.
  • The coating achieved 99% bactericidal activity, maintained after 4 weeks in PBS and 3 reuse cycles.
  • Exhibited excellent biocompatibility and hemocompatibility.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a250a0b7def13d035e1a593https://doi.org/10.1021/acs.langmuir.6c01452
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Also Consider

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  3. 3Straightforward Preparation of Polyurethane-based Biomaterials with Dual Antibacterial and Anti-Adhesive Properties for Long-Lasting Catheter Applications2025
  4. 4Straightforward Preparation of Polyurethane‐Based Biomaterials with Dual Antibacterial and Anti‐Adhesive Properties for Long‐Lasting Catheter Applications2025
  5. 5Tannic Acid-Based Coatings Containing Zwitterionic Copolymers for Improved Antifouling and Antibacterial Properties2024 · 9 citations