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The study aims to uncover the regulatory mechanisms of muscle development in different species to improve cultured meat production.

June 7, 2026Applied Food ResearchOpen Access

Toward efficient cultured meat: A transcriptomic framework identifying conserved pathways, species-specific markers, and limitations for industrial applications

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Comparative transcriptomic analysis reveals myogenesis insights for cultured meat applications, suggesting biological pathways and markers.

The study aims to uncover the regulatory mechanisms of muscle development in different species to improve cultured meat production.
Comparative transcriptomic analysis using public microarray datasets from Mus musculus and Bos taurus.
Identification of developmentally regulated genes and pathway-level themes despite species-specific differences.
Analysis included thousands of genes in cattle and mice, highlighting differential expression patterns.
Identified 7,119 developmentally regulated genes in cattle and 3,790 in mice, with significant transcriptional changes (adjusted p<0.05, |log₂FC|>1).
Only 18 orthologous genes showed differential expression across species, indicating limited overlap (<0.5%).
Notable bovine genes (MB, MYH1, CKM) and strong murine embryonic Hbb-y enrichment were observed, emphasizing distinct species differences.

Hajihassani et al. (2026) studied this question.

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Comparative transcriptomic analysis reveals myogenesis insights for cultured meat applications, suggesting biological pathways and markers.