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April 28, 2026AUDIOLOGY JAPANOpen Access

Juvenile-onset bilateral sensorineural hearing loss caused by MYO6 gene variants.

Kotaro Ishikawa Shinya Nishio Shinichi Usami

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Key Points

This research aims to identify the genetic cause of juvenile-onset bilateral sensorineural hearing loss, specifically focusing on MYO6 gene variants.
Patient diagnosed at 50 years with bilateral sensorineural hearing loss
Genetic testing identified a novel heterozygous nonsense variant in the MYO6 gene
Family history of hearing loss considered
Patient experienced progressive hearing loss, diagnosed at 60 dB at age 45
Genetic test revealed a pathogenic MYO6 variant (c.2122C>T: p.Arg708)
Emphasizes the importance of genetic testing in early-onset hearing loss cases

Implication

Investigates MYO6 gene variants affecting bilateral sensorineural hearing loss, suggesting genetic testing for early-onset cases.

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Cite This Study

Ishikawa et al. (2026) studied this question.

synapsesocial.com/papers/6a250a3c7def13d035e1a6ba https://doi.org/10.4295/audiology.69.72

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Clinical Details of Low-Frequency Hearing Loss Observed in Autosomal Dominant MYO7A-Associated Hearing Loss PatientsOriginal Research · 2026
2Simultaneous MT-RNR1 and MYO15A Mutations in a Family with Non-Syndromic Hearing Loss2025
3A novel MYO6 variant identified in a Chinese family with autosomal dominant non-syndromic hearing lossOriginal Research · 2026
4Three MYO15A Mutations Identified in One Chinese Family with Autosomal Recessive Nonsyndromic Hearing LossOriginal Research · 2018 · 15 citations
5The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B2024 · 24 citations

Targeted Next-Generation Sequencing Analysis Reveals a Novel Genetic Variant in <i>MYO6</i> Gene in an Indian Family with Postlingual Nonsyndromic Hearing Loss2024
A novel missense variant in MYO3A is associated with autosomal dominant high‐frequency hearing loss in a German family2020
Mutation Detection in MYO15A Gene in an Iranian Family with Non-Syndromic Hearing Loss2024
Clinical Characteristics of Hearing Loss Caused by the Autosomal Dominant TMC1 p.Asp572Asn Variant: Estimation of Hearing Progression Based on Sibling Cases and Previously Reported PatientsAUDIOLOGY JAPAN · 2026
Examination of divided attention in individuals with listening difficulties using a visual-auditory dual taskAUDIOLOGY JAPAN · 2026

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