Why the study?
The comparative value of single-time versus cumulative average triglyceride-glucose (TyG)-based indices for predicting new-onset CVD remained uncertain.
Do elevated triglyceride-glucose (TyG)-related indices predict new-onset cardiovascular disease in middle-aged and older adults?
Population
5,028 middle-aged and older adult participants from CHARLS and ELSA cohorts
Comparison
Seven single-time vs seven cumulative average TyG-based indicators
Design
Longitudinal cohort study
Follow-up
Median 5.0 years in CHARLS and 13.5 years in ELSA
Key result
Cumulative TyG-BRI was robustly associated with new-onset cardiovascular disease across cohorts, with an HR of 1.54 (95% CI 1.27-1.86) for the highest versus lowest quartile.
Authors
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May support TyG-BRI for CVD risk prediction in aging adults; leaves open incremental utility and prospective validation.
Cohort (n=5,028)
Yes
Do elevated triglyceride-glucose (TyG)-related indices predict new-onset cardiovascular disease in middle-aged and older adults?
Hazard Ratio: 1.54 (95% CI 1.27–1.86)
Cumulative TyG-BRI is a robust predictor of new-onset cardiovascular disease across different aging cohorts, with hypertension partly mediating this risk.
Zhu et al. (2026) conducted a cohort in Cardiovascular disease (n=5,028). Cumulative average triglyceride-glucose (TyG)-based indicators (CumTyG-BRI) vs. Lowest quartile (Q1) was evaluated on Incident cardiovascular disease (HR 1.54, 95% CI 1.27-1.86). Cumulative TyG-BRI was robustly associated with new-onset cardiovascular disease across cohorts, with an HR of 1.54 (95% CI 1.27-1.86) for the highest versus lowest quartile.