What does this research mean for the field?

Photodynamic therapy is a biologically multifaceted treatment that modifies tumor behavior by simultaneously initiating multiple interconnected cell death pathways, potentially overcoming tumor resistance to single-pathway therapies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to explore the molecular mechanisms underlying photodynamic therapy (PDT) and its therapeutic significance in oncology.

June 7, 2026Biomedicine & PharmacotherapyOpen Access

Molecular response of photodynamic therapy in oncology: A comprehensive review

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Authors

NNNkune Williams NkuneUniversity of Johannesburg HAHeidi AbrahamseUniversity of Johannesburg

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Implication

Comprehensive review outlines various cellular responses to photodynamic therapy in oncology, suggesting its multifaceted therapeutic implications.

Key Points

This review aims to explore the molecular mechanisms underlying photodynamic therapy (PDT) and its therapeutic significance in oncology.
Conducted a comprehensive review of existing literature on PDT, focusing on its molecular responses and biological mechanisms.
Discussed the roles of photosensitizers, light parameters, and molecular oxygen in the PDT process.
Highlighted current limitations and future perspectives on PDT, including improvements in photosensitizer design and combination therapies.
PDT induces direct cytotoxicity and engages multiple regulated cell death pathways, including apoptosis and necroptosis.
The effectiveness of PDT is linked to its ability to modify the tumor microenvironment and overcome resistance to therapies that trigger single pathways.
Future advancements in PDT are aimed at enhancing photosensitizer targeting and exploring combination strategies with immunotherapy.

Cite This Study

Nkune et al. (2026) studied this question.

synapsesocial.com/papers/6a250a717def13d035e1a8de https://doi.org/10.1016/j.biopha.2026.119584

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Implication

Comprehensive review outlines various cellular responses to photodynamic therapy in oncology, suggesting its multifaceted therapeutic implications.

Molecular response of photodynamic therapy in oncology: A comprehensive review

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular response of photodynamic therapy in oncology: A comprehensive review

Discussion

Member takes

Implication

Key Points

Cite This Study

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