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This research aims to uncover how cisplatin damages specific genes and its effect on protein-driven signalling pathways.

June 7, 2026Metallomics

Genomic Mapping Reveals Cisplatin Disruption of Protein Phosphorylation Signalling Genome-Wide

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Randomized trial investigates cisplatin's impact on protein signalling in human lung cancer cells, suggesting widespread disruption.

This research aims to uncover how cisplatin damages specific genes and its effect on protein-driven signalling pathways.
Constructed an HMGB1a-based affinity probe to isolate 1,2-cisplatin-crosslinked DNA.
Mapped cisplatin-damaged genes in human lung cancer cells using high throughput gene sequencing.
Performed bioinformatics analysis to assess impacts on protein kinase and phosphatase genes.
Mapped a total of 16,216 cisplatin-damaged genes (CDGs) with fold-enrichment > 1.5.
Cisplatin affected 85% (440) of human protein kinase genes and 81% (110) of human protein phosphatase genes.
Demonstrated significant decreases in expression of key protein kinase genes, indicating a broad disruption of protein phosphorylation signalling.

Qi et al. (2026) studied this question.

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