1519-P: Association of Physical Activity Intensity with Body Composition and Bone Health in People with Type 1 Diabetes

Introduction and Objective: Physical activity intensity may differentially influence body composition and skeletal health in people with type 1 diabetes (T1D). The aim of the current study was to examine the associations of objectively measured light, moderate, and vigorous physical activity with body composition and bone parameters. Methods: This cross-sectional analysis included 273 people with T1D (54.2% males, 45.8% females). Physical activity was assessed using a wrist-worn accelerometer over 7 consecutive days. Multivariable linear regression models adjusted for age, sex, and body mass index (BMI) were used to examine associations of light, moderate, and vigorous physical activity with total tissue fat, total fat mass, total lean mass, relative skeletal muscle index (RSMI). bone mineral content (BMC) and total bone mineral density (BMD). Results: Light physical activity was associated with lower total tissue fat (β-coefficient [95% CI] 2.22 [−4.28, −0.15], p=0.035) and total fat mass (−0.002 [−0.003, -0.00004], p=0.045). Moderate physical activity showed similar inverse associations with total tissue fat (−1.38 [−2.35, −0.41], p=0.005) and total fat mass (−0.001 [−0.002, -0.0004], p=0.003). Vigorous activity was also strongly associated with lower total tissue fat (−0.20 [-0.29, -0.11], p<0.001) and total fat mass (−0.0001, [-0.0002, -0.00005], p= 0.001). Light and moderate intensity physical activity were not associated with lean mass, BMD or BMC. In contrast, vigorous physical activity was positively associated with total total lean mass (0.0001 [0.00002, 0.0002], p= 0.015), RSMI (0.40 [0.10, 0.70], p= 0.008), BMD (4.99 [1.33, 8.65], p= 0.008) and BMC (0.001 [0.0001, 0.003], p=0.042). Conclusion: In people with T1D, all intensities of physical activity appear beneficial for adiposity, whereas only vigorous physical activity is beneficial for lean mass and bone health. These findings underscore the importance of physical activity intensity in optimizing musculoskeletal and body composition outcomes in people with T1D. Disclosure J. AlKandari: None. M. Irshad: None. S. Mourad: None. D. Alsaeed: None. A. Al-Ozairi: None. A.S. Mashankar: None. S.R. Gray: None. E. Alozairi: None. Funding The manpower used in this study has been funded by the Kuwait Foundation of Advancement of Science (KFAS) and the Ministry of Health, Kuwait.