Early pregnancy markers of insulin resistance, including AdipoIR, HOMA-IR, and fasting insulin, significantly predicted the development of hypertensive disorders of pregnancy (p < 0.02).
Cohort (n=52)
No
Do cardiometabolic health indices in early pregnancy predict the development of hypertensive disorders of pregnancy in pregnant individuals?
Markers of insulin resistance in early pregnancy, including AdipoIR, HOMA-IR, and fasting insulin, significantly predict the development of hypertensive disorders of pregnancy independent of BMI.
p-value: p=< 0.02
Introduction and Objective: The rate of hypertensive disorders of pregnancy (HDP) is rising. HDP has been linked to pre-existing cardiometabolic (CM) risk factors, including insulin resistance (IR), BMI, blood lipids, and lactate. Therefore, we sought to understand if an association exists between these markers in early pregnancy and development of HDP in our population. Methods: This cohort was derived from two prospective studies of CM health in pregnant individuals through 22 weeks gestation at a regional academic medical center. Fasting venous blood draws were performed. Differences between groups (those that developed HDP and those that did not) were assessed using T-test and Mann-Whitney U, as appropriate, and binary logistic regression was used to assess which factors predicted subsequent HDP diagnosis. Results: A total of 52 individuals were included in our analysis, with 24 (46.2%) developing HDP (Table). AdipoIR, HOMA-IR, and fasting insulin values were significant predictors of HDP. When controlling for maternal age, gestational age at study visit, and pre-pregnancy BMI, AdipoIR, HOMA-IR, and fasting insulin values remained significant predictors of HDP (p 0.02). Conclusion: Despite a relatively small sample, markers of IR significantly predicted HDP, even when controlling for maternal age and BMI. Future studies with a larger sample should focus on specific indices of IR and their thresholds for risk assessment of developing HDP. Disclosure R. Purvis: None. N. Zite: None. J. van Nes: None. J.M. Locklear: None. J.M. Mills: None. C. Tucker: None. D.P. Hamilton: None. C. Reeder: None. K.B. Fortner: Other - DMC Committee member for RSV vaccine; Current; Pfizer Inc. J.M. Maples: None.
Purvis et al. (Fri,) conducted a cohort in Hypertensive disorders of pregnancy (n=52). Insulin resistance markers (AdipoIR, HOMA-IR, fasting insulin) was evaluated on Development of hypertensive disorders of pregnancy (HDP) (p=< 0.02). Early pregnancy markers of insulin resistance, including AdipoIR, HOMA-IR, and fasting insulin, significantly predicted the development of hypertensive disorders of pregnancy (p < 0.02).