2-PUB: Lipoprotein(a) and Kidney Failure Appear to Be Interlinked in an Elderly African American Population at Risk of CVD

Introduction and Objective: Lipoprotein (a) [Lp(a)] is associated with higher risk of cardiovascular disease (CVD) incidence particularly when high such as above 125nmol/lt. We studied the relationship between Lp(a) and common CKD markers such as serum estimated glomerular filtration rate (eGFR), Urine creatinine, Urine-Albuminuria (UA), and Urine albuminuria/creatinine ratio (UACR) in an elderly African American population. Though similar data exists in Caucasian younger population that are at a high CVD risk, similar data is lacking in elderly non Caucasian population. Methods: We analyzed a total of 44 patient visits in an ongoing clinical trial [NCT06110130] where we analyzed the average of Lp(a) and CKD markers such eGFR and UACR. We specifically studied patients with Lp(a)>125 nmol/L Though none of our patients had overt diabetes a section had prediabetes. Results: The average age was 66.95±1.2 years in a predominantly African American cohort. The mean Lp(a) was 131.5±14.6 nmol/L. The mean eGFR was 40.98±1.5 mL/min/1.73mE2 [19.0 to 61.0]. The mean Urine Creatinine was 128.6±9.2 mg/dL [23.0 to 272.0]. The mean Urine Albuminuria was 4.4±0.86 mg/dL [1.0 to 22.9]. The mean UACR was 32.13±9.3 mg/g [1.0 to 328.0]. Lp(a) had a negative correlation with eGFR, y = -0.029x. However, we did not see any definitive correlation between Lp(a) and UACR with y = -0.25x. UA however had a clear negative correlation with Lp(a), y = -0.028x. Conclusion: In an elderly population with CKD the eGFR decreases with lipoprotein(a), indicating that they are at a high risk for CVD. This may also imply that elderly patients who have higher lipoprotein (a) are at an increased risk of rapid worsening of eGFR and CKD progression. It is therefore important to check Lp(a) in CKD patients even in absence of overt diabetes and treat appropriately to reduce high CVD risk and that may help halt CKD progression. We believe this is first clinical trial that has investigated the link between Lp(a) and eGFR, in an elderly population without diabetes of predominantly African American ethnicity. Disclosure S. Sen: None. Funding IIS supported by BI