2964-LB: Cardiovascular Health (Life’s Essential 8), Mortality Risk, and Life Expectancy in Type 2 Diabetes and Cardiometabolic Multimorbidity: Insights from UK Biobank

Introduction and Objective: This study examined associations between cardiovascular health (Life's Essential 8, LE8) and mortality in those with type 2 diabetes (T2D), coronary heart disease (CHD), stroke, and cardiometabolic multimorbidity (CMM), and quantified corresponding life expectancy gains. Methods: This prospective cohort study analyzed UK Biobank data from 24,479 participants (mean age 59.8 years; 65.3% men) with at least one cardiometabolic disease at baseline: T2D (n=11,745), CHD (n=4,748), stroke (n=4,891), and CMM (≥2 conditions, n=3,095). Primary outcomes were all-cause and cardiovascular mortality. Cox models assessed mortality risk by LE8 category. Weighted quantile sum regression identified key LE8 components. Flexible parametric survival models estimated life expectancy gains. Results: Each 10-point LE8 increase reduced all-cause mortality in T2D (HR 0.90, 95% CI 0.86-0.94), CHD (HR 0.79, 0.74-0.85), stroke (HR 0.89, 0.85-0.94), and CMM (HR 0.87, 0.82-0.92), with similar cardiovascular mortality patterns. Combined LE8 components exerted a protective association, with smoking contributing the largest weight. At age 65, high LE8 survival gains were 1.18 years (T2D), 5.38 years (CHD), 2.41 years (stroke), and 2.40 years (CMM) (Figure). Conclusion: Higher LE8 scores were associated with reduced mortality and extended life expectancy in these populations. Disclosure Y. Yuan: None. Y. Park: None. J.Y. Jeon: None. D. Lee: None. Funding National Research Foundation of Korea (NRF- 20241A5C3A02043449)