Çocukluk Çağı Menenjit ve Ensefalit Tanısında Multiplex PCR Panelinin Değerlendirilmesi: Retrospektif Bir Kohort Çalışması

Yusuf Serhat Karakeci; Kamil Yılmaz; Nida Özcan

doi:10.5798/dicletip.1964867

June 5, 2026Dicle Medical Journal / Dicle Tip DergisiOpen Access

Çocukluk Çağı Menenjit ve Ensefalit Tanısında Multiplex PCR Panelinin Değerlendirilmesi: Retrospektif Bir Kohort Çalışması

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Key Points

This study aims to evaluate the epidemiological distribution of pathogens detected by multiplex PCR in suspected childhood meningitis and encephalitis cases and their relationship with clinical outcomes.
Retrospective analysis of 26 patients aged 0-18 from January 1, 2020, to November 1, 2024, with positive multiplex PCR results from cerebrospinal fluid.
Demographic characteristics, clinical complaints, laboratory, and imaging findings were analyzed.
Average age of subjects was 5.42±4.25 years with 61.5% male; common complaints were fever (84.6%) and vomiting (76.9%).
Bacterial pathogens detected in 46.1% (n=12) and viral pathogens in 53.9% (n=14) of cases; most common were Streptococcus pneumoniae (75%) for bacterial and Enteroviruses (57.2%) for viral.
Significantly higher levels of platelets (394.78±133.82 x10³/uL), albumin (4.01±0.49 g/dL), and calcium (9.79±0.50 mg/dL) in viral compared to bacterial meningitis groups (p<0.05).

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Implication

Retrospective cohort study assesses outcomes linked to multiplex PCR findings in childhood meningitis and encephalitis cases, indicating its clinical significance.

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Karakeci et al. (2026) studied this question.

synapsesocial.com/papers/6a250b0e7def13d035e1b149 https://doi.org/10.5798/dicletip.1964867

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Çocukluk Çağı Menenjit ve Ensefalit Tanısında Multiplex PCR Panelinin Değerlendirilmesi: Retrospektif Bir Kohort Çalışması

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Discussion

Cite This Study

Çocukluk Çağı Menenjit ve Ensefalit Tanısında Multiplex PCR Panelinin Değerlendirilmesi: Retrospektif Bir Kohort Çalışması

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Discussion

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