Shows the effectiveness of 18 F-FDG PET/CT in localising infections in patients with pyrexia of unknown origin, suggesting improved management.
Pyrexia of unknown origin (PUO) remains a diagnostic challenge when clinical and routine investigationsare inconclusive. 18 F-Fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) serves as a whole-body imaging tool for detecting occult infectious foci. We report a case of prolonged PUO initially misdiagnosed as adult-onset Still’s disease, where 18 F-FDG PET/CT localised the infectious focus to the bilateral testis. Clinically asymptomatic for testicular involvement, tumour markers were normal, an ultrasound done after PET/CT supported orchitis, and serology confirmed brucellosis. The patient responded to targeted antimicrobial therapy. This case highlights the pivotal role of FDG PET/CT in localising clinically occult infectious foci and directly influencing management in patients with PUO.
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Dhir et al. (2026) studied this question.
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