1501-P: Awareness of Long-Term Impact of Gestational Diabetes Mellitus and Its Association with Future Cardiometabolic Outcomes

Introduction and Objective: Gestational Diabetes Mellitus (GDM) has long-term implications for both maternal and child health. Our study aims to assess the awareness of these implications and explore its link to long-term cardiometabolic outcomes. Methods: 300 women from the LEGEND cohort were analyzed. Awareness was assessed via a online questionnaire including Knowledge-Attitude-Practice (KAP) three parts. Factors influencing knowledge level were analyzed. Based on the average total KAP score, participants were divided into a good (n=138) and a poor awareness group (n=162) to further assess the link between the awareness and long-term cardiometabolic health. Results: The mean age of participants was 46.1±4.3 years and a median postpartum time of 14 years. 56.3% had glucose metabolism disorders, 53.3% had hyperlipidemia, 7.7% had coronary artery calcification (CAC) and 3.3% had peripheral artery disease (PAD). The average knowledge score was 9.6 ± 7.8 (out of a total score of 22). Awareness rates of the specific long-term health impacts of GDM were as follows: impaired glucose tolerance 78.7%, metabolic abnormalities around 60% (like insulin resistance and dyslipidemia) and non-metabolic complications <50% (including cardiovascular, renal, and neurocognitive diseases). Multivariate analysis identified higher knowledge scores in women aged 30-40, with higher education or income, delivery in public hospitals, frequent GDM knowledge acquisition, excellent attitude/practice levels(P<0.05). The poor awareness group had a higher risk of diabetes (HR 1.7, 95% CI: 1.0-2.8) and composite cardiovascular disease (CAC or PAD) (HR 2.6, 95% CI: 1.2-5.6) after excluding participants with pre-existing diabetes and cardiovascular disease. Conclusion: The knowledge of long-term GDM impacts is relatively low in women with prior GDM. The poor awareness is linked to a higher diabetes and cardiovascular disease risk. Hence, strengthening health education is crucial to improve awareness and long-term cardiometabolic health. Disclosure Q. Zhang: None. Z. Zhu: None. Y. Gao: None. Y. Zhang: None.