What question did this study set out to answer?

This study aims to investigate the impact of fasting on de novo lipogenesis in the liver and kidney of diabetic mice compared to non-diabetic controls.

June 7, 2026Diabetes

1382-P: Fasting Reveals Tissue-Specific Dysregulation of De Novo Lipogenesis in Diabetic Mice

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This study aims to investigate the impact of fasting on de novo lipogenesis in the liver and kidney of diabetic mice compared to non-diabetic controls.
Male B6.BKS(D)-Lepr db/J diabetic mice and non-diabetic controls were subjected to fasting for 2, 4, or 8 hours or remained fed until euthanasia.
Molecular markers were assessed alongside fractional palmitate synthesis measured via deuterated water and quantified by LC/MS.
Lipid metabolic regulation was evaluated in both the liver and kidney tissues.
Fasting maintained elevated malonyl-CoA levels in diabetic db/db mice, while levels decreased in non-diabetic controls.
In db/db mice, fasting increased fractional palmitate synthesis in both organs, while gene expression of lipogenic markers increased in the liver.
Fasting decreased SREBP1c protein levels in the kidney, highlighting complex metabolic adaptations in diabetic conditions.

Authors

ADAlethia DixonAnn Arbor Center for Independent Living SCSAROJ CHAKRABORTYAnn Arbor Center for Independent Living PKPRADEEP KAYAMPILLYAnn Arbor Center for Independent Living

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Implication

Randomized trial reveals tissue-specific metabolic responses to fasting in diabetic mice, indicating disease progression mechanisms.

Cite This Study

Dixon et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b1fd https://doi.org/10.2337/db26-1382-p

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1382-P: Fasting Reveals Tissue-Specific Dysregulation of De Novo Lipogenesis in Diabetic Mice

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Cite This Study

1382-P: Fasting Reveals Tissue-Specific Dysregulation of De Novo Lipogenesis in Diabetic Mice

Key Points

Discussion

Implication

Cite This Study

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