What does this research mean for the field?

Cardiovascular and cancer mortality in people with diabetes display distinct risk profiles, with cardiovascular death strongly linked to male sex and dementia, whereas cancer death is primarily linked to smoking. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research compares cardiovascular and cancer mortality risk profiles in individuals with diabetes.

June 7, 2026

2268-P: Distinct Risk Profiles for Cardiovascular and Cancer Mortality in People with Diabetes from the UK Biobank

Key Points

This research compares cardiovascular and cancer mortality risk profiles in individuals with diabetes.
Analyzed data from 28,043 adults with diabetes in the UK Biobank.
Used cause-specific Cox models adjusted for demographic and clinical factors.
Followed participants for a median of 11.8 years.
Detected 6,037 deaths during follow-up (28.4% cardiovascular; 24.5% cancer).
Cardiovascular mortality was significantly associated with male sex (HR 2.39, 95% CI 2.12-2.71) and dementia (HR 1.81, 95% CI 1.52-2.17).
Cancer mortality was primarily linked to smoking (HR 1.52, 95% CI 1.34-1.73), with dementia showing an inverse relationship.

Abstract

Introduction and Objective: Cardiovascular disease and cancer are leading causes of death in people with diabetes. We aimed to compare their associated risk profiles. Methods: We studied 28,043 adults with diabetes from the UK Biobank and compared cardiovascular and cancer mortality using cause-specific Cox models adjusted for key demographic and clinical factors. Results: Over a median follow-up of 11.8 years, 6,037 deaths occurred (28.4% cardiovascular; 24.5% cancer). Cardiovascular mortality was strongly associated with male sex (HR 2.39, 95% CI 2.12-2.71) and dementia (HR 1.81, 95% CI 1.52-2.17). Cancer mortality was most strongly associated with smoking (HR 1.52, 95% CI 1.34-1.73), while dementia showed an inverse association. Conclusion: Cardiovascular and cancer mortality in diabetes display distinct risk profiles, supporting phenotype-informed risk stratification. Disclosure J. Calvo-Marin: Speaker's Bureau; Current; Novo Nordisk, AstraZeneca, Abbott Diabetes, Roche Diabetes Care. V. Mora-Gomez: None. F. Ruiz Salazar: Speaker's Bureau; Current; Abbott Diagnostics, AstraZeneca, Novo Nordisk A/S. Advisory Panel; Current; Roche Diagnostics. M. Lutz: None. G. Torrealba-Acosta: None.

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