Deconfounded, quantitative microbiome profiling identifies robust multiple sclerosis markers and clinical covariate associations

Q: What does this research mean for the field?

Deconfounded quantitative microbiome profiling identifies robust gut microbiome markers associated with multiple sclerosis, including specific abundance changes in primary progressive multiple sclerosis (PPMS). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ayla Pauwels; Lindsay Devolder; Gwen Falony; Miguel D'haeseleer; Guy Nagels; Ann Van Remoortel; Muriel Derrien; Marie D’hooghe; J Raes

doi:10.1080/19490976.2026.2681876

June 5, 2026Gut MicrobesOpen Access

Deconfounded, quantitative microbiome profiling identifies robust multiple sclerosis markers and clinical covariate associations

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Key Points

The aim is to identify robust markers for multiple sclerosis and understand their relationship with clinical factors.
Quantitative microbiome profiling utilized to examine microbiome abundance
Controlled for confounding variables to ensure accurate results
Analyzed associations between microbiome markers and clinical characteristics in multiple sclerosis
Identified several strong disease markers linked to multiple sclerosis
Demonstrated significance of confounder control in microbiome studies
Emphasized distinct associations between microbiome profiles and clinical covariates in multiple sclerosis

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Implication

Identifies disease markers and clinical associations in multiple sclerosis, highlighting the significance of microbiome study.

Abstract

abundance in PPMS. Overall, our study provides robust disease markers and emphasizes the importance of QMP and confounder control.

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Pauwels et al. (2026) studied this question.

synapsesocial.com/papers/6a250b2d7def13d035e1b299 https://doi.org/10.1080/19490976.2026.2681876

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Deconfounded, quantitative microbiome profiling identifies robust multiple sclerosis markers and clinical covariate associations

Key Points

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Abstract

Discussion

Cite This Study

Deconfounded, quantitative microbiome profiling identifies robust multiple sclerosis markers and clinical covariate associations

Key Points

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Implication

Abstract

Discussion

Cite This Study

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