2932-LB: Regional Gray Matter Volume in Youth with Type 2 Diabetes, Obesity Alone, and Lean Controls

Introduction and Objective: Growing evidence demonstrates differences in the brain among youth with type 2 diabetes (T2D) and obesity compared to peers, including lower brain volume, cerebral blood flow, and cognitive scores. These studies have been conducted in relatively small cohorts. Larger studies are needed in youth-onset obesity and T2D to better characterize the impact of these early onset conditions on brain health in adolescence during a time of rapid brain development. Methods: Magnetic resonance imaging (MRI) was performed on 158 participants across three groups: youth with obesity with T2D (n=50, 72% female, 16.9 ± 1.8 yrs), obesity alone (n=53, 68% female, 16.1 ± 1.7 yrs), and lean controls (n=55, 56% female, 16.3 ± 2.1 yrs). Analysis focused on group differences in regional gray matter volume (GMV) with voxelwise significance evaluated at a family-wise error-corrected α=0.05. Results: Significant differences in GMV were found across the brain between the three groups (Figure). Similar patterns of pairwise group differences were found demonstrating a stepwise decrease in observed GMV (T2D<obesity alone<lean controls) after adjusting for age, sex, household income, and total intracranial volume. Conclusion: This work represents the largest study to date assessing GMV in youth-onset obesity and T2D. Results suggest obesity is associated with reduced GMV, while T2D may confer an even greater detrimental effect to GMV beyond obesity alone in adolescence. Disclosure R. Brady: None. A. Shah: Consultant; Ended; AbbVie Inc.