Key result
Self-reported OSA links to higher waist circumference but not independently to metabolic syndrome.
Why the study?
Obstructive sleep apnea and metabolic syndrome disorders contribute to adverse cardiovascular events, but their relationship in Latino patients in Southern Arizona required evaluation.
Is self-reported obstructive sleep apnea associated with metabolic syndrome traits in Latino patients?
Cross-Sectional (n=2,903)
Yes
Is self-reported obstructive sleep apnea associated with metabolic syndrome traits in Latino patients?
In a Latino cohort, self-reported obstructive sleep apnea is strongly associated with central adiposity, but its association with overall metabolic syndrome is largely explained by age and sex.
Self-reported OSA may flag central adiposity in Latinos; leaves open independent links to metabolic syndrome.
Introduction and Objective: Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) disorders contribute to adverse cardiovascular events. OSA involves the repeated collapse of the upper airway, leading to partial or complete cessation of airflow. MetS is characterized by increased triglycerides, hypertension, decreased HDL cholesterol, abdominal obesity, and hyperglycemia. Our study aimed to evaluate the relationship between self-reported OSA diagnosis (SR-OSA) and MetS criteria in Latino patients in Southern Arizona (n=2,903). Methods: Data on age, sex, body mass index (BMI), waist circumference, triglycerides, fasting plasma glucose (FPG), HDL cholesterol, blood pressure (BP), and SR-OSA were collected from participants in El Banco por Salud at UA and El Rio and Mariposa Community Health Centers in Tucson and Nogales, Arizona. Logistic and linear regression analyses were performed in R using unadjusted and adjusted models. Results: Overall, 52.8% of participants met the criteria for MetS, and 13.0% had SR-OSA. SR-OSA prevalence was higher in participants with MetS than in those without MetS in unadjusted analyses (14.3% versus 11.5%; p=3.3E-2). SR-OSA was significantly associated with older age and male sex (p=1.3E-6, p=1.7E-3). However, the association between SR-OSA and MetS was no longer significant after controlling for age and sex. In age- and sex-adjusted models, SR-OSA was strongly associated with higher waist circumference (β=0.81, p=3.3E-42), lower HDL cholesterol (β=-0.13, p=4.7E-2), and lower systolic BP (β=-0.18, p=4.2E-3). Triglycerides, diastolic BP, and FPG were not significantly associated with SR-OSA. Conclusion: SR-OSA is strongly associated with abdominal obesity in this Latino population, whereas its association with MetS appears to be largely explained by age and sex. These findings highlight the potential importance of central adiposity in SR-OSA and warrant further investigation of underlying mechanisms. Disclosure P. Kilrain: None. N. Fatima: None. L.F. Soltani: None. Y. Klimentidis: None. D.K. Coletta: None. L.J. Mandarino: None.
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KILRAIN et al. (2026) conducted a cross-sectional in Obstructive sleep apnea and metabolic syndrome (n=2,903). Self-reported obstructive sleep apnea (SR-OSA) vs. No SR-OSA was evaluated on Metabolic syndrome (MetS). Self-reported obstructive sleep apnea was strongly associated with higher waist circumference (β=0.81, p=3.3E-42), whereas its association with metabolic syndrome was explained by age and sex.
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