What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Metabolic Syndrome (n=152). Intervention: Obstructive Sleep Apnea vs. No Obstructive Sleep Apnea. Primary outcome: Triglycerides criteria (OR 3.26, 95% CI 1.47-7.21, p=0.004).

What does this research mean for the field?

Unrecognized obstructive sleep apnea in patients with metabolic syndrome is independently associated with elevated triglycerides (OR 3.26) and glucose (OR 2.31), contributing to metabolic dysregulation and systemic inflammation regardless of daytime sleepiness. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 11, 2010PLoS ONEOpen Access

The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic Syndrome

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Key result

Unrecognized obstructive sleep apnea in patients with metabolic syndrome was independently associated with elevated triglycerides (OR 3.26) and glucose (OR 2.31).

Why the study?

Does the presence of obstructive sleep apnea exacerbate metabolic dysregulation and systemic inflammation in patients with metabolic syndrome?

Study Design

Type

Cross-Sectional (n=152)

Multicenter

Structured PICO

Does the presence of obstructive sleep apnea exacerbate metabolic dysregulation and systemic inflammation in patients with metabolic syndrome?

Population

152 consecutive asymptomatic outpatients newly diagnosed with Metabolic Syndrome (ATP III criteria), mean age 48, 62.5% male, from Brazil. Exclusions: established cerebrovascular disease, coronary disease, heart failure, rheumatologic diseases, renal failure, hypothyroidism, pregnancy, history of smoking, regular exercisers, previous diagnosis of OSA, and use of hypoglycemic medications, insulin, fibrates, statins, uricosuric agents, steroids, or contraceptives.

Intervention

Presence of Obstructive Sleep Apnea (OSA), defined as an apnea-hypopnea index (AHI) ≥15 events per hour of sleep.

Comparator

Absence of Obstructive Sleep Apnea (OSA), defined as an apnea-hypopnea index (AHI) <15 events per hour of sleep.

Outcome

Levels of metabolic and inflammatory markers (blood pressure, glucose, triglycerides, cholesterol, LDL, cholesterol/HDL ratio, triglycerides/HDL ratio, uric acid, and C-reactive protein) and their independent association with OSA.surrogate

Main Result

Effect estimate: OR 3.26 (95% CI 1.47-7.21)

p-value: p=0.004

Unrecognized obstructive sleep apnea is highly prevalent in patients with metabolic syndrome and is independently associated with worse metabolic and inflammatory profiles, regardless of daytime sleepiness.

Limitations

Relatively small number of participants
Patients were middle-aged and without a history of coronary disease and stroke or intake of statins, fibrates and hypoglycemic drugs
Unable to exclude patients on anti-hypertensive treatment
Cross-sectional nature of the study does not prove cause-effect relationships
Middle-aged population without history of coronary disease/stroke or intake of statins/fibrates/hypoglycemic drugs limits generalizability
Cross-sectional nature does not prove cause-effect relationships

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports OSA evaluation in metabolic syndrome; leaves open whether treatment improves metabolic parameters.

Cite This Study

Drager et al. (2010) conducted a cross-sectional in Metabolic Syndrome (n=152). Obstructive Sleep Apnea vs. No Obstructive Sleep Apnea was evaluated on Triglycerides criteria (OR 3.26, 95% CI 1.47-7.21, p=0.004). Unrecognized obstructive sleep apnea in patients with metabolic syndrome was independently associated with elevated triglycerides (OR 3.26) and glucose (OR 2.31).

synapsesocial.com/papers/6a1306c006ed52b5c2c0f2cf https://doi.org/10.1371/journal.pone.0012065

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The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic Syndrome

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

The Impact of Obstructive Sleep Apnea on Metabolic and Inflammatory Markers in Consecutive Patients with Metabolic Syndrome

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider