Metabolic changes and inflammation in obstructive sleep apnea

Objective:There are different results on low grade inflammation and metabolic syndrome in patients with OSA. We investigated the relation between low grade inflammation and metabolic syndrome in patients with OSA. Method:The study included 78treatment-naive OSA patients and 28 control group. Clinical information, BMI, SF-36, Epworth Sleepiness Scale, and serum CRP were collected. Overnight polysomnography and blood sampling was taken for glucose, insulin, cholesterol, triglycerides. Metabolic syndrome was defined according to NCEP criteria. Each patient was assigned a metabolic score according to the number of discrete components of metabolic syndrome. Results: The components number and percentage of the metabolic syndrome and CRP levels were significantly higher in the patients with OSA than control group Table 1-Characteristics of Study Sample Control group n:28 Patients with OSA n:78 p Age 43.4±13.8 48.6±9.1 0.06 Gender male/female 18/10 63/15 0.07 Epworth Sleepiness Score 6.4±11.7 10.6±6.0 0.02 Smoking p/y 6.7±12.2 13.9±15.9 0.01 BMI kg/m2 26.3±4.2 29.8±4.8 0.001 Total metabolic score 1.2±0.8 2.1±0.9 0.0001 Metabolic Syndrome (%) 7.4 33.3 0.009 CRP levels mg/L 2.6±2.9 4.3±4.1 0.01 . The component number of metabolic syndrome was correlated with theCRP, AHI and desaturation index. The component number of metabolic syndrome increased with an increase in AHI and desaturation index in multivariate analysis independently obesity. Conclusion: OSA is associated with metabolic syndrome and low grade inflammation. The severity of the metabolic syndrome increased with an increase in OSA severity. Therapeutic approaches to OSA may decrease cardiovascular risk by decreasing frequency of metabolic syndrome in patients with OSA.