What does this research mean for the field?

In adults undergoing ambulatory ophthalmic surgery under mild-to-moderate sedation, GLP-1RA use is not associated with pulmonary aspiration or clinically relevant desaturation, despite an increased risk of postoperative nausea and vomiting. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study evaluates the association of GLP-1RA use with desaturation and PONV during ambulatory ophthalmic surgery.

June 7, 2026Diabetes

2842-LB: Risk of Pulmonary Aspiration with Glucagon-Like Peptide 1 Receptor Agonists in Mild-to-Moderate Sedation

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Authors

BHBrian HyungMontreal Neurological Institute and Hospital XYXiang Y. YePrincess Margaret Cancer Centre MCMano ChandrakumarUniversity of Toronto

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Implication

Retrospective cohort study assesses GLP-1RA impacts on desaturation and PONV during ambulatory ophthalmic surgery, indicating safety for selected patients.

Key Points

This study evaluates the association of GLP-1RA use with desaturation and PONV during ambulatory ophthalmic surgery.
Retrospective observational cohort study conducted at Kensington Eye Institute between Jan 2022- Dec 2024
Included 45,607 adults undergoing ophthalmic surgery under mild-to-moderate sedation
Compared outcomes between GLP-1RA users and non-users using logistic regression.
GLP-1RA use was not associated with desaturation (<90%): OR 1.15 (0.40-3.33), p=0.79
GLP-1RA users had an increased likelihood of PONV requiring antiemetics: OR 1.986 (1.32-2.972), p<0.001
No aspiration events occurred in either group during the perioperative period.

Cite This Study

Hyung et al. (2026) studied this question.

synapsesocial.com/papers/6a250b707def13d035e1b7a7 https://doi.org/10.2337/db26-2842-lb

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Implication

Retrospective cohort study assesses GLP-1RA impacts on desaturation and PONV during ambulatory ophthalmic surgery, indicating safety for selected patients.

2842-LB: Risk of Pulmonary Aspiration with Glucagon-Like Peptide 1 Receptor Agonists in Mild-to-Moderate Sedation

Discussion

Member takes

Implication

Key Points

Cite This Study

2842-LB: Risk of Pulmonary Aspiration with Glucagon-Like Peptide 1 Receptor Agonists in Mild-to-Moderate Sedation

Discussion

Member takes

Implication

Key Points

Cite This Study

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