Cover illustration shows how varying salt concentrations affect alpha-synuclein phase behavior, implying important physiological implications.
This cover-style schematic illustrates the salt-regulated phase behavior of α-synuclein in solution. A gradually deepening background suggests an increase in salt concentration from the center outward. Under low-salt conditions, multicolored α-synuclein chains assemble into dense, liquid-like condensates. In contrast, at higher salt concentrations, ionic screening weakens intermolecular interactions, suppresses clustering, and promotes the dispersion and diffusion of the protein chains throughout the solution.
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