2554-P: Evaluation of Antidiabetic Potential of Syzygium heyneanum Leaves Extract in Alloxan-Induced Diabetic Rats with Elevated Blood Sugar and Hitopathological Assessment of Pancreas

Introduction and Objective: Diabetes is a metabolic disorder characterized by persistent hyperglycemia, reaching organ damaging proportion. Prolonged usage of diabetes medicines showed irreversible side effects on metabolism; therefore, there is a need to shift to more plant-based medicines which are safe. Syzygium heyneanum has been long used as a traditional medicine source for different diseases. The effectiveness and validation of Syzygium heyneanum for antidiabetic activity require trials and biochemical studies. Methods: This study evaluated the potential of Syzygium heyneanum aqueous extract (SHA) and Syzygium heyneanum ethanol extract (SHE) in combating diabetes in alloxan-induced diabetic rats. All experimental rats were treated with different doses of SHA and SHE for 28 days. Results: Both extracts showed normalization of blood glucose level, body weight, and lipid profile of rats. The SHE showed high efficiency over SHA in treating diabetes and improving islets of Langerhans morphology. The presence of kauren 10-ol acetate at a retention time of 18.443 with a peak area of 58.75% in the GC-MS of SHE, exerts antidiabetic effects. Conclusion: These results demonstrate that the Syzygium heyneanum leaves extract exhibit antidiabetic activity by lowering blood glucose levels, improving the lipid profile, and regenerating the islets of Langerhans with any significant side effect. Disclosure F. Khan: None. S.Q. Raza: None.