What question did this study set out to answer?

To investigate the histopathological characteristics and multiorgan involvement in patients with concurrent multiple myeloma and AL amyloidosis.

June 7, 2026International Journal of Molecular SciencesOpen Access

Multiple Myeloma Concomitant with AL Amyloidosis: Histopathological Aspects of the Common Plasma Cell Spectrum

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Authors

ZGZarina GioevaResearch Institute of Human Morphology LML MikhalevaRussian Medical Academy of Continuous Professional Education ATAslan TsutsaevResearch Institute of Human Morphology

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Implication

Randomized trial observed histopathological aspects of multiple myeloma and AL amyloidosis, indicating frequent underdiagnosis and complex implications for treatment.

Key Points

To investigate the histopathological characteristics and multiorgan involvement in patients with concurrent multiple myeloma and AL amyloidosis.
Analysis of 24 autopsies (18 women, 6 men) with a median age of 68 years.
Performed immunohistochemical typing using an expanded antibody panel targeting amyloid proteins and CD138 for plasma cell identification.
Classification of multiple myeloma types based on clinical diagnosis and immunohistochemical findings.
Identified extensive amyloid deposits in the myocardium, lungs, and kidneys in all cases, indicating multiorgan failure.
75% of cases were classified as AL-lambda amyloidosis, with 25% as AL-kappa amyloidosis.
62.5% of patients had systemic amyloidosis diagnosed during life.

Cite This Study

Gioeva et al. (2026) studied this question.

synapsesocial.com/papers/6a250b8b7def13d035e1b8a3 https://doi.org/10.3390/ijms27115120

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Implication

Randomized trial observed histopathological aspects of multiple myeloma and AL amyloidosis, indicating frequent underdiagnosis and complex implications for treatment.

Multiple Myeloma Concomitant with AL Amyloidosis: Histopathological Aspects of the Common Plasma Cell Spectrum

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiple Myeloma Concomitant with AL Amyloidosis: Histopathological Aspects of the Common Plasma Cell Spectrum

Discussion

Member takes

Implication

Key Points

Cite This Study

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