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This research aims to explore the link between the small intestinal microbiome and type 2 diabetes subphenotypes.

June 7, 2026Diabetes

2661-P: The Human Small Intestinal Microbiome Is Linked with Type 2 Diabetes and a High-Risk Subphenotype

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Randomized trial shows increased bacterial load in type 2 diabetes subphenotypes, indicating risk for complications.

This research aims to explore the link between the small intestinal microbiome and type 2 diabetes subphenotypes.
Collected jejunal content from 627 individuals undergoing bariatric surgery.
Extracted microbial DNA using a protocol for low-abundance samples.
Quantified microbes via digital PCR for bacterial, fungal, and archaeal content.
Individuals with type 2 diabetes had higher bacterial levels (median=1410 GC/mL) than those without (median=902 GC/mL), p=0.0014.
High-risk diabetes cluster had significantly higher bacterial DNA (median=9908 GC/mL) compared to mild obesity-related cluster (median=13623 GC/mL), p=0.039.
No significant associations were found for archaea and fungi levels.

Makour et al. (2026) studied this question.

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