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This study aims to understand how cagrilintide affects feeding behavior through specific brain circuits in mice.

June 7, 2026Diabetes

2458-P: Arcuate Hypothalamic Circuits Mediate Acute Cagrilintide-Induced Feeding in Mice

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This study aims to understand how cagrilintide affects feeding behavior through specific brain circuits in mice.
Assessed neuronal activation in CalcR-cre-tdTomato mice after cagrilintide administration (10 nmol/kg)
Chemogenetically activated XCTR+ neurons in ARC to evaluate feeding response
Silenced ARC CTR+ neurons using a Cre-dependent tetanus toxin strategy to examine the necessity for anorectic effects.
Cagrilintide increased cFos expression in ARC CTR+ neurons, indicating direct target engagement
Chemogenetic activation of ARC neurons led to rapid weight gain and increased food intake
Silencing ARC CTR+ neurons impaired cagrilintide's acute anorectic effect, with chronic treatment showing reduced cumulative intake.

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Randomized trial assesses cagrilintide's effects on feeding in mice, suggesting key neural pathways involved.

Lommi et al. (2026) studied this question.

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