What question did this study set out to answer?

To examine how endometrial and systemic immunity changes during the menstrual cycle in women with and without endometriosis.

June 7, 2026

Deep immune profiling of endometrial and peripheral blood cells in endometriosis.

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Observational study reveals altered immune cell dynamics in endometriosis, suggesting immune involvement in fertility issues.

To examine how endometrial and systemic immunity changes during the menstrual cycle in women with and without endometriosis.
Cross-sectional immune phenotyping study of 40 participants (28 with endometriosis, 12 controls).
Analysis of endometrial and peripheral blood samples using spectral flow cytometry for immune profiling.
Multiplex immunohistochemical imaging of uterine biopsies to assess immune cell spatial organization.
Endometriosis patients showed reduced endometrial early natural killer (NK) cells (P.adj = 0.006).
Increased MAIT-like CD8+ T cells were observed in the endometriosis group (P.adj = 0.033).
Cyclical variation in peripheral immunity included increased early NK cells (P.adj = 0.001) and decreased effector CD4 and CD8 T cells (P.adj = 0.002).

Kisovar et al. (2026) studied this question.

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