Why the study?
Prediabetes and diabetes are established CVD risk factors, but how dynamic glucose fluctuations relate to CVD risk in individuals without diabetes remains unclear.
Do CGM-derived measures and 2-h post-MMTT glucose associate with estimated 10-year CVD risk in adults without diabetes?
Population
1374 Framingham Heart Study participants free of diabetes and CVD
Comparison
Standardized CGM-derived measures and 2-h post-MMTT glucose levels
Design
Cross-sectional observational study
Key result
Higher 2-h post-MMTT glucose and CGM measures were associated with higher odds of intermediate or high 10-year CVD risk (ORs 1.21-1.70, p<0.001) in adults without diabetes.
Authors
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Dynamic glycemia metrics link to CVD risk in nondiabetics; extends evidence but leaves open clinical utility pending prospective studies.
Observational (n=1,374)
Do CGM-derived measures and 2-h post-MMTT glucose associate with estimated 10-year CVD risk in adults without diabetes?
Effect estimate: OR 1.21-1.70
p-value: p=<0.001
Dynamic measures of glycemia, such as CGM-derived metrics and post-MMTT glucose, are associated with higher estimated 10-year CVD risk in adults without diabetes, independent of fasting plasma glucose.
Bakhshi et al. (2026) conducted an observational in Adults without diabetes and cardiovascular disease (n=1,374). Higher 2-h post-MMTT glucose and CGM measures was evaluated on Intermediate/high 10-year CVD risk (PREVENT score ≥7.5%) (OR 1.21-1.70, p=<0.001). Higher 2-h post-MMTT glucose and CGM measures were associated with higher odds of intermediate or high 10-year CVD risk (ORs 1.21-1.70, p<0.001) in adults without diabetes.