Review examines the impact of exercise-induced myokines on rehabilitation outcomes and metabolic regulation, suggesting therapeutic applications.
Recent research on exercise has introduced a new biological dimension by demonstrating that skeletal muscle functions not only as a mechanical structure but also as an endocrine organ. Myokines released from skeletal muscle during exercise play critical roles in metabolic regulation, inflammation control, nervous system function, and tissue regeneration. Consequently, growing research interest has focused on elucidating the biological and therapeutic significance of myokines. This review examines the effects of exercise-induced myokines on clinical rehabilitation and metabolic regulation, highlighting their therapeutic potential in neurological and cardiac rehabilitation as well as in the management of metabolic syndrome, while emphasizing the biological properties and functional roles of the most extensively studied myokines.
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ÖZTÜRK et al. (2026) studied this question.
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