Randomized trial demonstrates enhanced skin rejuvenation in aging mice via novel collagen liposome delivery system, indicating significant therapeutic potential.
The supplementation of exogenous collagen is an effective strategy for combating skin aging─a complex physiological process characterized by the continuous degradation of endogenous collagen─its therapeutic efficacy has been severely limited due to poor transdermal permeability. In this study, we developed a novel noninvasive transdermal delivery system (Rh2-CLs) that effectively and safely delivers natural collagen via a novel liposome formulation for aging skin rejuvenation. The permeability of collagen was significantly enhanced by the encapsulation in the optimized liposomes, demonstrating a more than 4-fold improvement in transdermal delivery efficiency compared to free collagen. Circular dichroism spectroscopy confirmed that the encapsulation of liposomes did not disrupt the integrity of the collagen triple-helical structure, thus maintaining its original bioactivity. In a photoaged mouse model, the topical application of Rh2-CLs markedly reduced skin wrinkling and improved skin elasticity. Histological assessments revealed that Rh2-CLs effectively alleviated UV-induced damage and promoted the rapid restoration of skin structure and function through the supplementation and induction of collagen regeneration. In summary, the ginsenoside Rh2-based liposome platform offers a safe, efficient, and noninvasive strategy for transdermal collagen delivery, demonstrating considerable potential for applications in skin regeneration and cosmetic dermatology.
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Li et al. (2026) studied this question.
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