Biomarkers of kidney involvement in paediatric IgA vasculitis: a systematic review and meta-analysis

Q: What does this research mean for the field?

While biomarkers such as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and fecal occult blood test show statistically significant associations with kidney involvement in pediatric IgA vasculitis, clinically actionable predictors for IgA vasculitis nephritis currently remain lacking. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Madalina Andreea Beldie; Márk Hernádfői; Karen Krisztina Fazekas; Dóra Luca Bodócs; P ter Hegyi; Csaba Lódi; Iuliana Magdalena Stârcea

doi:10.1007/s00467-026-07382-8

June 5, 2026Pediatric NephrologyOpen Access

Biomarkers of kidney involvement in paediatric IgA vasculitis: a systematic review and meta-analysis

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Key Points

To evaluate serum and urinary biomarkers' prognostic value for predicting IgA vasculitis nephritis in paediatric patients.
Conducted systematic review and meta-analysis of biomarkers in paediatric IgA vasculitis patients.
Included retrospective, prospective and cross-sectional studies reporting biomarker levels.
Data analyzed using a random-effects model, following PRISMA guidelines and QUIPS quality assessment.
129 studies involving 23,726 patients were included.
Neutrophil-to-lymphocyte ratio was higher in patients with nephritis (0.48; 95% CI 0.04-0.93).
Positive faecal occult blood test associated with increased odds of kidney involvement (OR 2.04; 95% CI 1.05-3.96).

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Implication

Systematic review evaluates biomarkers predicting kidney involvement in paediatric IgA vasculitis, indicating future validation is needed.

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Cite This Study

Beldie et al. (2026) studied this question.

synapsesocial.com/papers/6a250be87def13d035e1bf97 https://doi.org/10.1007/s00467-026-07382-8

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Biomarkers of kidney involvement in paediatric IgA vasculitis: a systematic review and meta-analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Biomarkers of kidney involvement in paediatric IgA vasculitis: a systematic review and meta-analysis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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