What does this research mean for the field?

Red dichromatic imaging with indigo carmine (RDI-indigo) achieves a diagnostic accuracy of 85.0% for identifying deep submucosal invasion in colorectal tumors, suggesting it can serve as a viable complementary alternative to magnifying chromoendoscopy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the effectiveness of red dichromatic imaging with indigo carmine in diagnosing deep submucosal invasion in colorectal tumors.

June 7, 2026DiagnosticsOpen Access

Assessment of Red Dichromatic Imaging with Indigo Carmine for Identifying Deep Submucosal Invasion in Colorectal Tumors: A Pilot Study

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Authors

TFToshiki FutakuchiJikei University School of Medicine NTNaoto TamaiJikei University School of Medicine MFMai FukudaJikei University School of Medicine

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Implication

Pilot study evaluates red dichromatic imaging's accuracy for deep invasion in colorectal tumors, suggesting clinical promise.

Key Points

This study aims to evaluate the effectiveness of red dichromatic imaging with indigo carmine in diagnosing deep submucosal invasion in colorectal tumors.
Obtained 90 images from 30 colorectal tumor cases using RDI-indigo, NBI, and MCE.
Endoscopists classified images with JNET and pit pattern classifications.
Correlational analysis was done for JNET type 3 and pit pattern with pathological depth ≥pT1b.
Diagnostic accuracy for ≥pT1b was 85.0% for RDI-indigo (95% CI: 79.8–90.2%).
Intraobserver agreement between RDI-indigo and MCE showed Cohen’s kappa = 0.39, indicating fair agreement.
Interobserver agreement was moderate for MCE (Fleiss’ kappa = 0.56) and fair for RDI-indigo (Fleiss’ kappa = 0.36).

Cite This Study

Futakuchi et al. (2026) studied this question.

synapsesocial.com/papers/6a250c1c7def13d035e1c35d https://doi.org/10.3390/diagnostics16111739

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Assessment of Red Dichromatic Imaging with Indigo Carmine for Identifying Deep Submucosal Invasion in Colorectal Tumors: A Pilot Study

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Key Points

Cite This Study

Assessment of Red Dichromatic Imaging with Indigo Carmine for Identifying Deep Submucosal Invasion in Colorectal Tumors: A Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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