This Preface introduces the Special Issue entitled, "Brain Bioenergetics in Aging: Neurovascular and Neurometabolic Coupling and Fuels," which is comprised of manuscripts contributed by invited speakers and program/organizing committee members who participated in the 15th International Conference on Brain Energy Metabolism (ICBEM) held on September 17-21, 2024, in Ljubljana, Slovenia. The conference covered the latest developments in research related to (i) coordination of neurometabolic and neurovascular coupling and homeostasis of energy metabolism in healthy aging and Alzheimer's disease, (ii) in vivo imaging modalities for study of neurometabolic and neurovascular coupling, (iii) mitochondrial and metabolic alterations and resilience in injured and aging brain, (iv) astrocyte metabolism in Alzheimer's and other neurodegenerative diseases, (v) microglial support of neuronal metabolism and role in neurodegeneration, (vi) neuronal mitochondria and disease, (vii) lipids and transporters in brain function, metabolism and Alzheimer's disease, and (viii) metabolic regulation of cognition. The special issue contains 19 manuscripts on these topics.
Drew et al. (Mon,) studied this question.