2345-P: Risk Factors for Postoperative Glucose Metabolic Disorders following Pancreatic Surgery: A Single-Center Cohort Study

Introduction and Objective: This study aims to investigate the clinical features and risk factors of newly developed glucose metabolism disorders following pancreatic surgery. Methods: A retrospective cohort study included 229 non-diabetic patients undergoing pancreatic surgery at Shanghai Changzheng Hospital (2017-2023). Preoperative serum was available for 108 patients. Participants were stratified into postoperative glucose metabolism disorders or normal glucose metabolism groups. Pre- and postoperative metabolic profiles were compared. Multivariate logistic regression identified risk factors and assessed the impact of surgical procedures. Results: (1) Baseline Data: Mean age was 45 ± 13 years, with 55.5% being male. Among primary conditions, benign lesions accounted for 27.9%, malignant lesions for 52.4%, and borderline lesions for 19.7%. Surgical procedures primarily involved pancreatoduodenectomy and pancreatic body-tail splenectomy. (2) After approximately 806.3 person-years of follow-up, 30.13% of patients who underwent pancreatic resection developed new-onset glucose metabolism disorders postoperatively. (3) Baseline fasting blood glucose, insulin, and glycated hemoglobin levels at baseline were not associated with the occurrence of post-operative glucose metabolism disorders (p > 0.05). The incidence of new-onset glucose metabolism disorders after pancreatic tail splenectomy was significantly higher than that after pancreaticoduodenectomy (p<0.05). Multivariate analysis identified resection extent (OR=3.21) and residual pancreatic volume (OR=0.72) as independent risk factors. Conclusion: Pancreatic surgery is a significant risk factor for postoperative glucose metabolism disorders. The surgical technique markedly influences incidence, with distal pancreatectomy carrying the highest risk. Affected patients primarily present with nocturnal hypoglycemia and insufficient insulin secretion. Disclosure X. Bi: None.