1517-P: “Weekend-Warrior” Physical Activity Reduces Depressive Symptoms in Adults with Type 2 Diabetes

Introduction and Objective: Depression is twice as prevalent in adults with type 2 diabetes (T2D) as the general population. Though higher frequency and duration of moderate-to-vigorous intensity physical activity (MVPA) are associated with improved depressive symptoms in the general population, their association with depressive symptoms in T2D is unknown. Methods: Data came from six NHANES cycles (2007-2018). Participants reported the typical number of days per week and typical duration that they performed bouts of MVPA lasting ≥10 min and were categorized as:1) inactive (none; reference), 2) insufficiently active (<150 min/week), 3) regularly active (≥150 min/week, ≥3 days/week), or 4) weekend warrior (≥150 min/week, 1-2 days/week). Patient Health Questionnaire-9 scores identified symptoms of depression, with a score of ≥10 denoting clinically significant depressive symptoms. Odds Ratios were estimated with survey-weighted logistic regression models. Results: Regularly active and weekend warrior had 41% and 78%, respectively, lower odds of depressive symptoms compared to inactive. The association for the regularly active was attenuated after adjusting for antidepressant use, but not weekend warrior. Weekend warrior had fewer median weekly minutes of MVPA than regularly active. Conclusion: In T2D, weekend warrior may be linked to reduced depressive symptoms, though more frequent MVPA (skipping no more than 2 consecutive days) is recommended for glycemic control. Disclosure S. Yousefi: None. S. Ehrlich: Research Support; Ended; Dexcom, Inc. C. Wagoner: None. C. Springer: None. B.R. Hallenbeck: None.