2299-P: Evolving Burden of Chronic Kidney Disease and In-Hospital Mortality among Type 2 Diabetes Mellitus Admissions in California Before and After the COVID-19 Pandemic (2016–2022)

Introduction and Objective: The COVID-19 pandemic disrupted healthcare delivery and may have accelerated kidney disease progression and worsened outcomes for diabetic populations. This study examines trends in CKD hospitalizations and mortality among T2DM admissions in California from 2016-2022. Methods: A retrospective analysis of T2DM admissions with CKD were identified using ICD-10 codes from California’s acute-care hospital discharge database. Annual age- and sex-adjusted CKD hospitalization and mortality rates were calculated using the U.S. Census 2000 standard. Pre-pandemic (2016-2019) and pandemic (2020-2022) differences were evaluated using multivariate logistic regression adjusting for age, sex, race/ethnicity, region, and payer source. Results: CKD hospitalizations among T2DM admissions rose from 816.8 per 100,000 in 2016 to 904.0 per 100,000 in 2022 (+10.7%). Rates were consistently higher in males than females. Mortality remained stable pre-pandemic (38.7-40.5 per 1,000) but increased in 2020 (58.3 per 1,000, +44%). Male mortality rose disproportionately (+51% vs. +37% in females). Mortality in 2022 (52.6 per 1000) remained above pre-pandemic levels. Conclusion: CKD hospitalization and mortality among T2DM patients in California increased during the pandemic, especially in males. Elevation in mortality underscores the need for proactive kidney-protective diabetes care. Disclosure L. Sasaki: None. L. Cantrell: None. K. Kim: None. M. Trinh: None. A.W. Ratnasiri: None.