Narrative review summarizes the roles of O-linked glycosylation in signaling and immune function, highlighting implications for disease.
Key Points
This review aims to differentiate the roles of mucin-type O-GalNAc glycosylation and intracellular O-GlcNAcylation in cellular functions and immune regulation.
Conducted targeted searches on PubMed and Web of Science using keywords related to O-glycosylation.
Reviewed literature regarding glycosylation systems and their biological functions and mechanisms.
Discussed glycosylation defects and their link to congenital disorders and disease phenotypes.