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June 15, 2026Molecular MetabolismOpen Access

Cross-Talk Between Glycosylation Pathways: Mechanistic Insights and Implications for Human Diseases

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Authors

NVNinon VeryIYIkram El Yazidi‐Belkoura

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Overview

This review uncovers the connections between glycosylation pathways and their implication in various diseases.

Key Points

  • This review aims to explore the interconnected nature of glycosylation pathways and their impact on human diseases.
  • Revising classical classifications of glycosylation within a modern systems-level framework.
  • Highlighting metabolic substrates and regulatory circuits linking glycosylation pathways.
  • Discussing examples from various diseases like cancer, metabolic disorders, and congenital disorders.
  • UDP-GlcNAc fluctuations drive coordinated remodeling across glycosylation pathways affecting cellular processes.
  • Dysregulation of glycosylation hubs correlates with multiple human diseases.
  • O-GlcNAcylation modulates stability and activity of glycosylation-related proteins and enzymes.

Cite This Study

Very et al. (2026) studied this question.

synapsesocial.com/papers/6a2f97c8a1cfeec490828e0fhttps://doi.org/10.1016/j.molmet.2026.102400
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Distinct O-Linked Glycosylation Systems in Signaling and Immune Regulation2026
  2. 2The O-GlcNAc dichotomy: when does adaptation become pathological?2023 · 4 citations
  3. 3Glycogen and Glycosylation: Friends or Foes?2026
  4. 4Glycomics in Human Diseases and Its Emerging Role in Biomarker Discovery2025 · 24 citations
  5. 5Beyond the sugar coating: mucin-type O-Glycosylation as an underappreciated player in brain function and disease2026