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This review synthesizes the molecular mechanisms and biological functions of protein glycosylation while evaluating its role in disease pathology and clinical applications.

August 5, 2024SHILAP Revista de lepidopterologíaOpen Access

Glycosylation: mechanisms, biological functions and clinical implications

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Authors

MHMengyuan HeShihezi University XZXiangxiang ZhouAnhui Polytechnic University XWXin WangBeihua University

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Implication

Review summarizes aberrant protein glycosylation patterns across human diseases, highlighting opportunities for targeted therapeutics and biomarker discovery.

Key Points

This review synthesizes the molecular mechanisms and biological functions of protein glycosylation while evaluating its role in disease pathology and clinical applications.
Evaluated enzymatic mechanisms of post-translational modification driven by glycosyltransferases in cellular systems.
Assessed structural composition and differential expression profiles of glycosylated protein residues.
Synthesized translational progress regarding glycan-targeted therapeutics, vaccines, and diagnostic biomarkers.
Glycosylation acts as a critical regulator of fundamental biological behaviors, including proper protein function, cell-matrix adhesion, and tumor immune evasion.
Aberrant glycosylation signatures directly correlate with the onset and progression of malignancies, inflammatory conditions, and autoimmune disorders.
Translating glycan structural analysis into clinical practice enables the identification of sensitive disease biomarkers, novel small-molecule drugs, and targeted vaccines.

Cite This Study

He et al. (2024) studied this question.

synapsesocial.com/papers/69da0dc6387cf70698685dcc https://doi.org/10.1038/s41392-024-01886-1

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Implication

Review summarizes aberrant protein glycosylation patterns across human diseases, highlighting opportunities for targeted therapeutics and biomarker discovery.

Glycosylation: mechanisms, biological functions and clinical implications

Discussion

Member takes

Implication

Key Points

Cite This Study

Glycosylation: mechanisms, biological functions and clinical implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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