On the Question of the Full Selective Synthesis of Potentially Bioactive of 2-(tert-Butyl)-3-hydroxy-7-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-ones and Their Derivatives: Experimental and DFT Computational Study

The practical aspects of the full regioselective preparation of 2-(tert-butyl)-3-hydroxy-7-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-1-ones and their derivatives were described. Created in our laboratory, the reaction protocol is simple and occurs under mild conditions. It is important that all obtained products are stable, pure, crystalline and can be easily identified based on spectral data and X-ray analysis results. Key aspects of the reaction course were explained based on the DFT quantum chemical calculations.