A 90-day structured digital lifestyle intervention reduced HbA1c by 1.46% compared to a 0.07% increase with standard of care (p<0.001), with higher adherence driving greater improvements.
Cohort (n=149)
Yes
Does a 90-day structured digital lifestyle intervention improve glycemic and anthropometric outcomes in patients with type 2 diabetes?
A 90-day structured digital lifestyle intervention with behavioral coaching significantly improves glycemic control and weight in patients with type 2 diabetes, with benefits driven largely by adherence.
Absolute Event Rate: 1.46% vs -0.07%
p-value: p=<0.001
Introduction and Objective: Optimal glycemic control in type 2 diabetes (T2D) remains elusive despite pharmacologic advances. Expert-coached digital platforms offer scalable lifestyle interventions, yet data linking adherence to significant glycemic outcomes remains sparse. This study assessed the value of regular adherence to interventions through a 90 day structured Digital program in both glycemic and anthropometric improvement. Methods: In a large multicenter study, T2D participants were allocated to a test group: TG (structured lifestyle intervention plus standard of care (SOC); n=87) or control group: CG (SOC only; n=62). TG was further stratified by high (35%) and low adherence (35%). TG received personalized intervention integrating circadian-aligned, tailored diet, exercise, and behavioral coaching, while the control group followed SOC. Glycemic and anthropometric parameters were assessed at baseline and follow-up. Statistical analyses were conducted with significance set at p0.05. Results: Among 87 test participants, HbA1c, FBS, BMI, and weight decreased by 1.46%±1.82, 19.87±55.51 mg/dL, 0.55±4.32 kg/m², and 1.49±13.18 kg (all p0.001), respectively. High adherence participants (n=62) showed greater reductions in HbA1c (1.7±1.5%), FBS (25.2±60 mg/dL), BMI (0.6±0.9 kg/m²), and weight (1.6±2.3 kg) than low adherence participants exhibited marginal reductions in HbA1c, FBS, BMI and weight (0.8±1.3%, 3.1±59.9 mg/dL, 0.5±0.8 kg/m²), and 1.4±2.1 kg), respectively. In contrast, CG showed slight glycemic worsening, reflected by upward shifts in HbA1c (0.07%) and FBS (10.84 mg/dL), with only marginal anthropometric improvement (BMI: 0.18 kg/m² and weight: 0.26 kg). Conclusion: This study shows that adherence-promoting behaviors, reinforced through frequent, empathetic one-on-one digital coaching, drive meaningful clinical improvements, highlighting the potential of continuous digital care in T2D and necessitating longitudinal follow-up. Disclosure A.M. Raymond: None. S. Kumar: None. A. Sequeira: None. J. Joseline: None. C.G. Mehra: None.
RAYMOND et al. (Fri,) conducted a cohort in Type 2 diabetes (n=149). Structured digital lifestyle intervention vs. Standard of care only was evaluated on Reduction in HbA1c (p=<0.001). A 90-day structured digital lifestyle intervention reduced HbA1c by 1.46% compared to a 0.07% increase with standard of care (p<0.001), with higher adherence driving greater improvements.