What does this research mean for the field?

BDNF and HIF-1α play complementary neuroprotective roles in neonatal hypoxic-ischemic injury, with BDNF acting as a potential prognostic biomarker for survival in neonates without neuronal injury and HIF-1α reflecting gestational age-dependent adaptive responses to stress. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to explore the roles of HIF-1α and BDNF in neonatal hypoxic-ischemic injury within different gestational age groups.

June 7, 2026International Journal of Molecular SciencesOpen Access

The Involvement of HIF-1α and BDNF in Neonatal Hypoxic–Ischemic Insult to the Cerebral Germinal Matrix

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Authors

FSFelipe Paes Gomes da SilvaPontifícia Universidade Católica do Paraná FSFrancys De Luca Fernandes da SilvaPontifícia Universidade Católica do Paraná NGNicolas Pereira GerberPontifícia Universidade Católica do Paraná

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Implication

Analyzes BDNF and HIF-1α in neonates with hypoxic-ischemic injury, indicating potential biomarkers for survival.

Key Points

This research aims to explore the roles of HIF-1α and BDNF in neonatal hypoxic-ischemic injury within different gestational age groups.
Analyzed 118 germinal matrix samples from neonates grouped by gestational age (EP, LP, T).
Investigated immunopositivity of HIF-1α and BDNF, correlating with asphyxia, neuronal injury, and survival.
Performed linear regression analysis to assess BDNF expression in relation to survival time.
BDNF expression positively associated with postnatal survival in non-injured neonates (ρ = 0.316; p = 0.012).
Average BDNF increase of 0.0077% per hour of survival (p < 0.001).
HIF-1α positively correlated with survival in asphyxiated extremely preterm neonates (ρ = 0.492; p = 0.024).

Cite This Study

Silva et al. (2026) studied this question.

synapsesocial.com/papers/6a250cbc7def13d035e1cdd0 https://doi.org/10.3390/ijms27115125

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The Involvement of HIF-1α and BDNF in Neonatal Hypoxic–Ischemic Insult to the Cerebral Germinal Matrix

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Cite This Study

The Involvement of HIF-1α and BDNF in Neonatal Hypoxic–Ischemic Insult to the Cerebral Germinal Matrix

Discussion

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Implication

Key Points

Cite This Study

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