1602-P: Exploring the Motivational and Contextual Factors Influencing the Decision of Black and Latino Adults to Enroll in a Diabetes Management Clinical Trial

Introduction and Objective: Black and Latino adults with diabetes remain underrepresented in clinical research due to limited understanding of trials, mistrust stemming from injustice, and language barriers. While tailored communication and transparent informed consent processes may improve research comprehension, limited research has examined the motivational and contextual factors influencing trial enrollment decisions. This study aimed to explore factors influencing enrollment of Black and Latinos in a Enhancing Diabetes Management with Pharmacists and Community Health Workers (ENRxICH) clinical trial and examine how novel health literacy guided orientation and informed consent videos influenced decision-making. Methods: Guided by the Capability, Opportunity, and Motivation - Behavior (COM-B) model, a qualitative descriptive exploratory study was done. Semi-structured interviews were conducted with 18 enrolled ENRxICH participants. Interviews explored participants’ perceptions of the enrollment process, motivations for participation, and the role of health literacy guided orientation and informed consent videos in enhancing understanding and trust. Thematic analysis was conducted with codes organized deductively based on the COM-B constructs, and inductively Results: Enrollment decisions were motivated by goals to lower A1c levels, gaining actionable diabetes knowledge, and benefit to family and community. Contextual support for enrollment included research team diverse representation, and opportunity to receive pharmacist and community health worker support and resources. Guided orientation and informed consent videos were perceived to enhance clarity, relevance, and trust, strengthening engagement in the enrollment process. Conclusion: Findings provide theory-driven insights to inform recruitment strategies that enhance comprehension, trust, and engagement among historically underrepresented populations in diabetes clinical research Disclosure J. Pouncy: None. S. Perez Torres: None. O.A. Tikare: None. M. Maurer: None. O. Shiyanbola: None.