What question did this study set out to answer?

This research aims to uncover the intrarenal genes and pathways affected by GLP-1 receptor agonists in chronic kidney disease.

June 7, 2026Diabetes

1113-OR: ADA Presidents' Select Abstract: Single-Cell Transcriptomic Profiling Identifies GLP-1RA Associated Pathways in Early Kidney Disease

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Randomized trial identifies GLP-1 receptor agonist pathways in kidney disease, suggesting novel intrarenal mechanisms.

This research aims to uncover the intrarenal genes and pathways affected by GLP-1 receptor agonists in chronic kidney disease.
Single-cell RNA sequencing (scRNA-seq) was performed on kidney biopsy tissue from 11 participants with kidney disease.
Differential gene expression analysis was conducted using NEBULA, focusing on GLP-1RA users versus non-users.
Gene set enrichment analysis was utilized to identify enriched pathways in various cell types.
Distinct vascular, immune, and tubular pathway signatures were observed with GLP-1RA use.
Angiogenesis pathways were enhanced in immune cells, whereas hypoxia and TNFα-NFκB signaling were reduced in immune myeloid cells.
Metabolic processes like glycolysis were boosted in endothelial and vascular smooth muscle cells, while multiple metabolic pathways were diminished in immune and tubular cells.

Choi et al. (2026) studied this question.

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