What does this research mean for the field?

Reduced first-trimester levels of PAPP-A and β-hCG are significantly associated with a higher risk of developing gestational diabetes mellitus, and their combined assessment yields high predictive accuracy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to identify first-trimester biomarkers that predict the risk of gestational diabetes mellitus (GDM).

June 7, 2026Journal of South Asian Federation of Obstetrics and GynaecologyOpen Access

Early Prediction of Gestational Diabetes Mellitus Using First-trimester Biomarkers: A Retrospective Study

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Authors

DSDhivya Senthilkumar SSSathya SelvarajanMadras Medical Mission SRSuryapriya RajendranAarupadai Veedu Medical College & Hospital

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Implication

Retrospective study evaluates first-trimester biomarkers for predicting gestational diabetes, suggesting improved early intervention.

Key Points

This study aims to identify first-trimester biomarkers that predict the risk of gestational diabetes mellitus (GDM).
Retrospective cohort study of 241 pregnant women at Sri Ramachandra Medical College and Hospital, Chennai.
Participants underwent first-trimester screening and oral glucose tolerance testing (OGTT).
Statistical analysis included t-tests, logistic regression, and ROC analysis.
First-trimester PAPP-A and β-hCG levels were significantly reduced in the GDM group (p < 0.001).
Logistic regression identified inverse associations between GDM and both PAPP-A (OR = 0.999) and β-hCG (OR = 0.914).
The combined assessment of β-hCG and PAPP-A showed improved predictive accuracy (AUC = 0.874; specificity = 90.5%).

Cite This Study

Senthilkumar et al. (2026) studied this question.

synapsesocial.com/papers/6a250ce97def13d035e1d138 https://doi.org/10.5005/jp-journals-10006-2862

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Early Prediction of Gestational Diabetes Mellitus Using First-trimester Biomarkers: A Retrospective Study

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Implication

Key Points

Cite This Study

Early Prediction of Gestational Diabetes Mellitus Using First-trimester Biomarkers: A Retrospective Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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